Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum ParaoxonaseArylesterase Activities in Streptozotocin-Induced Diabetic Rats

Abstract EN

The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats.

Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6).

Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes.

Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P < 0.01) and D + Vit B6 (P < 0.05) groups.

Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups.

Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P < 0.05).

GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group.

Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups.

The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.