Anticonvulsant Potential of Certain New (2E)‎-2-[1-Aryl-3-(1H-imidazol-1-yl)‎propylidene]-N-(arylH)‎hydrazinecarboxamides

Abstract EN

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a–p are reported.

The test compounds 6a–p exhibited anticonvulsant activity mainly in the scPTZ screen.

Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μmol/kg in the scPTZ screen without any neurotoxicity.

The assigned (E)-configuration of the title compounds 6a–p was confirmed via single crystal X-ray structure of compound 6g.