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Dietary Hyaluronic Acid Migrates into the Skin of Rats
Joint Authors
Masuda, Yasunobu
Matsuoka, Ryosuke
Oe, Mariko
Mitsugi, Koichi
Odanaka, Wataru
Yoshida, Hideto
Kanemitsu, Tomoyuki
Seino, Satoshi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Hyaluronic acid is a constituent of the skin and helps to maintain hydration.
The oral intake of hyaluronic acid increases water in the horny layer as demonstrated by human trials, but in vivo kinetics has not been shown.
This study confirmed the absorption, migration, and excretion of 14C-labeled hyaluronic acid (14C-hyaluronic acid).
14C-hyaluronic acid was orally or intravenously administered to male SD rats aged 7 to 8 weeks.
Plasma radioactivity after oral administration showed the highest level 8 hours after administration, and orally administered 14C-hyaluronic acid was found in the blood.
Approximately 90% of 14C-hyaluronic acid was absorbed from the digestive tract and used as an energy source or a structural constituent of tissues based on tests of the urine, feces, expired air, and cadaver up to 168 hours (one week) after administration.
The autoradiographic results suggested that radioactivity was distributed systematically and then reduced over time.
The radioactivity was higher in the skin than in the blood at 24 and 96 hours after administration.
The results show the possibility that orally administered hyaluronic acid migrated into the skin.
No excessive accumulation was observed and more than 90% of the hyaluronic acid was excreted in expired air or urine.
American Psychological Association (APA)
Oe, Mariko& Mitsugi, Koichi& Odanaka, Wataru& Yoshida, Hideto& Matsuoka, Ryosuke& Seino, Satoshi…[et al.]. 2014. Dietary Hyaluronic Acid Migrates into the Skin of Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049385
Modern Language Association (MLA)
Oe, Mariko…[et al.]. Dietary Hyaluronic Acid Migrates into the Skin of Rats. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1049385
American Medical Association (AMA)
Oe, Mariko& Mitsugi, Koichi& Odanaka, Wataru& Yoshida, Hideto& Matsuoka, Ryosuke& Seino, Satoshi…[et al.]. Dietary Hyaluronic Acid Migrates into the Skin of Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049385