Antihepatitis B Virus Activity of a Protein-Enriched Fraction from Housefly (Musca domestica) in a Stable HBV-Producing Cell Line
Joint Authors
Lu, Xuemei
Wang, Jie
Jin, Xiaobao
Chu, Fujiang
Zhu, Jiayong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Hepatitis B virus (HBV) infection remains a major public health problem.
Although several vaccines and therapeutic strategies are currently being implemented to combat HBV virus, effective antiviral therapy against HBV infection has not been fully developed.
Alternative strategies and new drugs to combat this disease are urged.
Insects and insect derivatives are a large and unexploited source of potentially useful compounds for modern medicine.
In the present study, we investigated the first anti-HBV activity of a protein-enriched fraction (PE) from the larvae of the housefly (Musca domestica) in a stable HBV-producing cell line.
HBsAg and HBeAg in the culture medium were measured by enzyme-linked immunosorbent assay.
HBV-DNA was quantified by fluorescent quantification PCR.
HBV core protein was assayed by immunofluorescent staining.
Results indicate PE treatment inhibited both HBsAg, HBeAg secretion, and HBV-DNA replication.
Furthermore, PE could also suppress HBV core protein expression.
PE could be a potential candidate for the development of a novel and effective drug for the treatment of HBV infection.
American Psychological Association (APA)
Lu, Xuemei& Jin, Xiaobao& Wang, Jie& Chu, Fujiang& Zhu, Jiayong. 2014. Antihepatitis B Virus Activity of a Protein-Enriched Fraction from Housefly (Musca domestica) in a Stable HBV-Producing Cell Line. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049424
Modern Language Association (MLA)
Lu, Xuemei…[et al.]. Antihepatitis B Virus Activity of a Protein-Enriched Fraction from Housefly (Musca domestica) in a Stable HBV-Producing Cell Line. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1049424
American Medical Association (AMA)
Lu, Xuemei& Jin, Xiaobao& Wang, Jie& Chu, Fujiang& Zhu, Jiayong. Antihepatitis B Virus Activity of a Protein-Enriched Fraction from Housefly (Musca domestica) in a Stable HBV-Producing Cell Line. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1049424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049424