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Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
Joint Authors
Jiang, Zhao-Cai
Qi, Wei-Jing
Wang, Jin-Yan
Luo, Fei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia.
The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia.
Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats.
The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively.
We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats.
In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level.
Increased pain thresholds were also observed in the sham rats after the chronic administration.
These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia.
American Psychological Association (APA)
Jiang, Zhao-Cai& Qi, Wei-Jing& Wang, Jin-Yan& Luo, Fei. 2014. Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049493
Modern Language Association (MLA)
Jiang, Zhao-Cai…[et al.]. Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1049493
American Medical Association (AMA)
Jiang, Zhao-Cai& Qi, Wei-Jing& Wang, Jin-Yan& Luo, Fei. Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1049493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049493