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Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches
Joint Authors
Barba, Marta
Cicione, Claudia
Bernardini, Camilla
Campana, Vincenzo
Pagano, Ernesto
Michetti, Fabrizio
Logroscino, Giandomenico
Lattanzi, Wanda
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders.
Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound.
Autogenous bone graft provides all these three qualities and is considered the gold standard.
However, a high morbidity is associated with the harvest procedure.
Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion.
In recent years, cell and gene therapies have attracted great interest from the scientific community.
The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications.
In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.
American Psychological Association (APA)
Barba, Marta& Cicione, Claudia& Bernardini, Camilla& Campana, Vincenzo& Pagano, Ernesto& Michetti, Fabrizio…[et al.]. 2014. Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049497
Modern Language Association (MLA)
Barba, Marta…[et al.]. Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049497
American Medical Association (AMA)
Barba, Marta& Cicione, Claudia& Bernardini, Camilla& Campana, Vincenzo& Pagano, Ernesto& Michetti, Fabrizio…[et al.]. Spinal Fusion in the Next Generation: Gene and Cell Therapy Approaches. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049497