Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Reactive carbonyls are widespread species in living organisms and mainly known for their damaging effects.
The most abundant reactive carbonyl species (RCS) are derived from oxidation of carbohydrates, lipids, and amino acids.
Chemical modification of proteins, nucleic acids, and aminophospholipids by RCS results in cytotoxicity and mutagenicity.
In addition to their direct toxicity, modification of biomolecules by RCS gives rise to a multitude of adducts and cross links that are increasingly implicated in aging and pathology of a wide range of human diseases.
Understanding of the relationship between metabolism of RCS and the development of pathological disorders and diseases may help to develop effective approaches to prevent a number of disorders and diseases.
On the other hand, constant persistence of RCS in cells suggests that they perform some useful role in living organisms.
The most beneficial effects of RCS are their establishment as regulators of cell signal transduction and gene expression.
Since RCS can modulate different biological processes, new tools are required to decipher the precise mechanisms underlying dual effects of RCS.
American Psychological Association (APA)
Semchyshyn, Halyna M.. 2013. Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049552
Modern Language Association (MLA)
Semchyshyn, Halyna M.. Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1049552
American Medical Association (AMA)
Semchyshyn, Halyna M.. Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects. The Scientific World Journal. 2013. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1049552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049552