Effect of Gamma Irradiation on Structural and Biological Properties of a PLGA-PEG-Hydroxyapatite Composite
Joint Authors
Shahabi, Sima
Najafi, Farhood
Majdabadi, Abbas
Hooshmand, Tabassom
Haghbin Nazarpak, Masoumeh
Karimi, Batool
Fatemi, Seyyed Mostafa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Gamma irradiation is able to affect various structural and biological properties of biomaterials In this study, a composite of Hap/PLGA-PEG and their ingredients were submitted to gamma irradiation doses of 25 and 50 KGy.
Various properties such as molecular weight (GPC), thermal behavior (DSC), wettability (contact angle), cell viability (MTT assay), and alkaline phosphatase activity were studied for the composites and each of their ingredients.
The results showed a decrease in molecular weight of copolymer with no change in the glass transition and melting temperatures after gamma irradiation.
In general gamma irradiation can increase the activation energy ΔH of the composites and their ingredients.
While gamma irradiation had no effect on the wettability of copolymer samples, there was a significant decrease in contact angle of hydroxyapatite and composites with increase in gamma irradiation dose.
This study showed an increase in biocompatibility of hydroxyapatite with gamma irradiation with no significant effect on cell viability in copolymer and composite samples.
In spite of the fact that no change occurred in alkaline phosphatase activity of composite samples, results indicated a decrease in alkaline phosphatase activity in irradiated hydroxyapatites.
These effects on the properties of PLGA-PEG-hydroxyapatite can enhance the composite application as a biomaterial.
American Psychological Association (APA)
Shahabi, Sima& Najafi, Farhood& Majdabadi, Abbas& Hooshmand, Tabassom& Haghbin Nazarpak, Masoumeh& Karimi, Batool…[et al.]. 2014. Effect of Gamma Irradiation on Structural and Biological Properties of a PLGA-PEG-Hydroxyapatite Composite. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049568
Modern Language Association (MLA)
Shahabi, Sima…[et al.]. Effect of Gamma Irradiation on Structural and Biological Properties of a PLGA-PEG-Hydroxyapatite Composite. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049568
American Medical Association (AMA)
Shahabi, Sima& Najafi, Farhood& Majdabadi, Abbas& Hooshmand, Tabassom& Haghbin Nazarpak, Masoumeh& Karimi, Batool…[et al.]. Effect of Gamma Irradiation on Structural and Biological Properties of a PLGA-PEG-Hydroxyapatite Composite. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049568