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Biochemical Characterization of Early Osteoarthritis in the Ankle
Joint Authors
Südkamp, Norbert P.
Langenmair, Elia Raoul
Henkelmann, Ralf
Salzmann, Gian M.
Niemeyer, Philipp
Schmal, Hagen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
Reliable data about in vivo regulation of cytokines in early ankle osteoarthritis (OA) are still missing.
Methods.
49 patients with a mean age of 33 ± 14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial.
Lavage fluids were analyzed by ELISA.
Additionally, clinical parameters and scores (FFI, CFSS, and AOFAS) were evaluated and supplemented by the Kellgren Lawrence Score (KLS) and the ankle osteoarthritis scoring system (AOSS).
Results.
ICRS grading of cartilage damage, previous operations, and duration of complains were strong indicators for OA progress and showed correlations to age, clinical scores, validated KLS, and AOSS ( P < 0.04 ).
Systemic and intraarticular inflammatory parameters were low in all patients.
Biochemically, aggrecan and BMP-7 positively indicated OA with statistically significant associations with duration of symptoms, FFI, AOFAS, and KLS ( P < 0.04 ).
In contrast, BMP-2 levels showed statistically significant negative correlations to aggrecan or BMP-7 concentrations, which is in line with the negative association with ICRS score and KLS and the positive correlation with FFI ( P < 0.03 ).
Conclusions.
We were able to identify different key markers of OA in the ankle as aggrecan, BMP-7, and BMP-2, offering starting points for new ways in diagnostics and interventional strategies.
American Psychological Association (APA)
Schmal, Hagen& Salzmann, Gian M.& Langenmair, Elia Raoul& Henkelmann, Ralf& Südkamp, Norbert P.& Niemeyer, Philipp. 2014. Biochemical Characterization of Early Osteoarthritis in the Ankle. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049621
Modern Language Association (MLA)
Schmal, Hagen…[et al.]. Biochemical Characterization of Early Osteoarthritis in the Ankle. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049621
American Medical Association (AMA)
Schmal, Hagen& Salzmann, Gian M.& Langenmair, Elia Raoul& Henkelmann, Ralf& Südkamp, Norbert P.& Niemeyer, Philipp. Biochemical Characterization of Early Osteoarthritis in the Ankle. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049621