Tumor Necrosis Factor- α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis
Joint Authors
Yuan, Haining
Lv, Bokun
Hu, Guang
Wang, Jian
Huang, Jie
Yan, Wenying
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants.
The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS.
Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013.
Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis.
The TNF-α test showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76, Q* = 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89, Q* = 0.87).
We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83).
A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity.
Accordingly, we suggest that TNF-α is also a valuable marker in the diagnosis of NS.
American Psychological Association (APA)
Lv, Bokun& Huang, Jie& Yuan, Haining& Yan, Wenying& Hu, Guang& Wang, Jian. 2013. Tumor Necrosis Factor- α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1049739
Modern Language Association (MLA)
Lv, Bokun…[et al.]. Tumor Necrosis Factor- α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1049739
American Medical Association (AMA)
Lv, Bokun& Huang, Jie& Yuan, Haining& Yan, Wenying& Hu, Guang& Wang, Jian. Tumor Necrosis Factor- α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis. The Scientific World Journal. 2013. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1049739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049739