Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol

Abstract EN

The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations.

Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds.

Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV.

No specific antiviral activity was observed in the cases at hand.

Novel compounds were prepared for future biological tests.