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Median Preoptic Nucleus Mediates the Cardiovascular Recovery Induced by Hypertonic Saline in Hemorrhagic Shock
Joint Authors
Pedrino, Gustavo Rodrigues
Amaral, Nathalia Oda
Naves, Lara Marques
Ferreira-Neto, Marcos Luiz
Freiria-Oliveira, André Henrique
Rosa, Daniel Alves
Reis, Angela Adamski da Silva
Ianzer, Danielle
Xavier, Carlos Henrique
Colombari, Eduardo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Changes in plasma osmolarity, through central and peripheral osmoreceptors, activate the median preoptic nucleus (MnPO) that modulates autonomic and neuroendocrine adjustments.
The present study sought to determine the participation of MnPO in the cardiovascular recovery induced by hypertonic saline infusion (HSI) in rats submitted to hemorrhagic shock.
The recordings of mean arterial pressure (MAP) and renal vascular conductance (RVC) were carried out on male Wistar rats (250–300 g).
Hemorrhagic shock was induced by blood withdrawal over 20 min until the MAP values of approximately 60 mmHg were attained.
The nanoinjection (100 nL) of GABA A agonist (Muscimol 4 mM; experimental group (EXP)) or isotonic saline (NaCl 150 mM; control (CONT)) into MnPO was performed 2 min prior to intravenous overload of sodium through HSI (3 M NaCl, 1.8 mL/kg, b.wt.).
Hemorrhagic shock reduced the MAP in control ( 62 ± 1.1 mmHg) and EXP ( 61 ± 0.4 mmHg) equipotently.
The inhibition of MnPO impaired MAP (CONT: 104 ± 4.2 versus EXP: 60 ± 6.2 mmHg) and RVC (CONT: 6.4 ± 11.4 versus EXP: -53.5 ± 10.0 ) recovery 10 min after HSI.
The overall results in this study demonstrated, for the first time, that the MnPO plays an essential role in the HSI induced resuscitation during hypovolemic hemorrhagic shock.
American Psychological Association (APA)
Amaral, Nathalia Oda& Naves, Lara Marques& Ferreira-Neto, Marcos Luiz& Freiria-Oliveira, André Henrique& Colombari, Eduardo& Rosa, Daniel Alves…[et al.]. 2014. Median Preoptic Nucleus Mediates the Cardiovascular Recovery Induced by Hypertonic Saline in Hemorrhagic Shock. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049841
Modern Language Association (MLA)
Amaral, Nathalia Oda…[et al.]. Median Preoptic Nucleus Mediates the Cardiovascular Recovery Induced by Hypertonic Saline in Hemorrhagic Shock. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049841
American Medical Association (AMA)
Amaral, Nathalia Oda& Naves, Lara Marques& Ferreira-Neto, Marcos Luiz& Freiria-Oliveira, André Henrique& Colombari, Eduardo& Rosa, Daniel Alves…[et al.]. Median Preoptic Nucleus Mediates the Cardiovascular Recovery Induced by Hypertonic Saline in Hemorrhagic Shock. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049841