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Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture
Joint Authors
Kang, Chao
Wen, Ting-Chi
Kang, Ji-Chuan
Meng, Ze-Bing
Li, Guang-Rong
Hyde, Kevin D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production.
In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production.
Using these culture conditions, a maximum production of cordycepin was 2008.48 mg/L for 700 mL working volume in the 1000 mL glass jars and total content of cordycepin reached 1405.94 mg/bottle.
This method provides an effective way for increasing the cordycepin production at a large scale.
The strategies used in this study could have a wide application in other fermentation processes.
American Psychological Association (APA)
Kang, Chao& Wen, Ting-Chi& Kang, Ji-Chuan& Meng, Ze-Bing& Li, Guang-Rong& Hyde, Kevin D.. 2014. Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1049903
Modern Language Association (MLA)
Kang, Chao…[et al.]. Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture. The Scientific World Journal No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1049903
American Medical Association (AMA)
Kang, Chao& Wen, Ting-Chi& Kang, Ji-Chuan& Meng, Ze-Bing& Li, Guang-Rong& Hyde, Kevin D.. Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1049903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049903