The Neurobiological Pathogenesis of Poststroke Depression
Joint Authors
Fang, Min
Liu, Xue-Yuan
Feng, Chao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Poststroke depression (PSD) is an important consequence after stroke, with negative impact on stroke outcome.
The pathogenesis of PSD is complicated, with some special neurobiological mechanism, which mainly involves neuroanatomical, neuron, and biochemical factors and neurogenesis which interact in complex ways.
Abundant studies suggested that large lesions in critical areas such as left frontal lobe and basal ganglia or accumulation of silent cerebral lesions might interrupt the pathways of monoamines or relevant pathways of mood control, thus leading to depression.
Activation of immune system after stroke produces more cytokines which increase glutamate excitotoxicity, results in more cell deaths of critical areas and enlargement of infarctions, and, together with hypercortisolism induced by stress or inflammation after stroke which could decrease intracellular serotonin transporters, might be the key biochemical change of PSD.
The interaction among cytokines, glucocorticoid, and neurotrophin results in the decrease of hippocampal neurogenesis which has been proved to be important for mood control and pharmaceutical effect of selective serotonin reuptake inhibitors and might be another promising pathway to understand the pathogenesis of PSD.
In order to reduce the prevalence of PSD and improve the outcome of stroke, more relevant studies are still required to clarify the pathogenesis of PSD.
American Psychological Association (APA)
Feng, Chao& Fang, Min& Liu, Xue-Yuan. 2014. The Neurobiological Pathogenesis of Poststroke Depression. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049951
Modern Language Association (MLA)
Feng, Chao…[et al.]. The Neurobiological Pathogenesis of Poststroke Depression. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1049951
American Medical Association (AMA)
Feng, Chao& Fang, Min& Liu, Xue-Yuan. The Neurobiological Pathogenesis of Poststroke Depression. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1049951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049951