Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish
Joint Authors
Pathania, Mallika
Semina, Elena V.
Duncan, Melinda K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We report analysis of the ocular lens phenotype of the recessive, larval lethal zebrafish mutant, lama1 a69/a69.
Previous work revealed that this mutant has a shortened body axis and eye defects including a defective hyaloid vasculature, focal corneal dysplasia, and loss of the crystalline lens.
While these studies highlight the importance of laminin α 1 in lens development, a detailed analysis of the lens defects seen in these mutants was not reported.
In the present study, we analyze the lenticular anomalies seen in the lama1 a69/a69 mutants and show that the lens defects result from the anterior extrusion of lens material from the eye secondary to structural defects in the lens capsule and developing corneal epithelium associated with basement membrane loss.
Our analysis provides further insights into the role of the lens capsule and corneal basement membrane in the structural integrity of the developing eye.
American Psychological Association (APA)
Pathania, Mallika& Semina, Elena V.& Duncan, Melinda K.. 2014. Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049969
Modern Language Association (MLA)
Pathania, Mallika…[et al.]. Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1049969
American Medical Association (AMA)
Pathania, Mallika& Semina, Elena V.& Duncan, Melinda K.. Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1049969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049969