Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The polymorphisms in the three main heat shock protein 70 (HSP70-1, HSP70-2, and HSP70-hom) genes were identified to be associated with cancer risk.
However, the results are inconsistent.
We perform a meta-analysis to evaluate the association between the three HSP70 polymorphisms and cancer risk.
Relevant studies were identified using PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases up to March 29, 2014.
The cancer risk associated with the HSP70 polymorphisms was estimated for each study by odds ratios (OR) together with its 95% confidence interval (CI), respectively.
Twenty case-control studies from eighteen publications were included; a significant association was observed for HSP70-2 polymorphism (dominant model: OR = 1.53, 95% CI: 1.11–2.09; recessive model: OR = 1.91, 95% CI: 1.06–3.45; AG versus AA: OR = 1.38, 95% CI: 1.03–1.84; GG versus AA: OR = 2.34, 95% CI: 1.21–4.54), while there was no significant association for HSP70-1 and HSP70-hom polymorphisms.
Besides, in stratification analyses by ethnicity, cancer type, and source of control, significant association was detected for HSP70-2 polymorphism, while for HSP70-hom polymorphism, we found a significant association in hospital-based population under homozygote comparison model.
This meta-analysis suggests that the HSP70-2 polymorphism rather than HSP70-hom and HSP70-1 polymorphisms was associated with the risk of cancer.
American Psychological Association (APA)
He, Lei& Deng, Tao& Luo, He-sheng. 2014. Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050043
Modern Language Association (MLA)
He, Lei…[et al.]. Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050043
American Medical Association (AMA)
He, Lei& Deng, Tao& Luo, He-sheng. Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050043