Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis
Joint Authors
Xiao, Guoguang
Xie, Xiaoping
Fan, Juan
Deng, Jianjun
Tan, Shan
Zhu, Yu
Guo, Qin
Wan, Chaomin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
There are no treatments with established efficacy for this disorder so far.
Aim.
To systematically review the efficacy of acotiamide in the treatment of patients with FD.
Methods.
We searched main electronic databases through November 2013.
RCTs evaluating the efficacy of acotiamide versus placebo in FD patients were included.
Pooled risk ratio (RR) with 95% confidential interval (CI) was calculated.
Results.
Six publications including seven RCTs were eligible for inclusion.
The summary RR of overall improvement of FD symptoms in patients receiving acotiamide versus placebo was 1.29 (95% CI, 1.19–1.40, P<0.00001; I2=15%).
Acotiamide improved the symptoms of patients with postprandial distress syndrome (PDS) (RR, 1.29; 95% CI, 1.09–1.53, P=0.003; I2=0%), and the summary RR for patients with epigastric pain syndrome (EPS) was 0.92 (95% CI, 0.76–1.11, P=0.39; I2=0%).
Acotiamide showed a significantly beneficial effect on the elimination of some individual FD symptoms compared with placebo.
Adverse events were not significantly different between acotiamide and placebo groups.
Subgroup analyses suggested that acotiamide 100 mg three times daily (tid) showed consistent efficacy not only for the overall improvement but also for the elimination of some individual symptoms in FD patients.
Conclusions.
Acotiamide has the potential to improve the symptoms of patients with FD, particularly of patients with PDS, without major adverse effects.
The dosage of acotiamide 100 mg tid might be the appropriate dose in the treatment of FD.
American Psychological Association (APA)
Xiao, Guoguang& Xie, Xiaoping& Fan, Juan& Deng, Jianjun& Tan, Shan& Zhu, Yu…[et al.]. 2014. Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050062
Modern Language Association (MLA)
Xiao, Guoguang…[et al.]. Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050062
American Medical Association (AMA)
Xiao, Guoguang& Xie, Xiaoping& Fan, Juan& Deng, Jianjun& Tan, Shan& Zhu, Yu…[et al.]. Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050062