Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status
Joint Authors
Elkabbany, Z. A.
Mahmoud, N. H.
Hamza, Rasha T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Because ghrelin is one of the key hormones in regulating feeding behavior and caloric status, it was suggested that ghrelin behavior might be closely associated with malnutrition state of patients with chronic liver disease (CLD).
Thus, we aimed to assess serum ghrelin levels in children with CLD and its relation to anthropometric parameters and severity of CLD.
Forty CLD patients were studied in comparison to 40 controls.
All subjects were subjected to history, anthropometric, and laboratory assessment of liver functions and serum acylated ghrelin.
Ghrelin was higher in patients than controls being higher with progress of Child’s grade and with deterioration of liver functions.
Hyperghrelinemia was detected in 62.5% of cases.
Ghrelin correlated negatively with body mass index standard deviation score (BMISDS ( r = - 0.95 , P < 0.001 )), triceps skin fold thickness (TSFT ( r = - 0.88 , P < 0.001 )), and subscapular skin fold thickness (SSFT ( r = 0.83 , P < 0.001 )) percentiles.
In conclusion, hyperghrelinemia may represent a compensatory mechanism trying to overcome malnutrition state complicating CLD and can be used as a parameter for early detection and assessment of the severity of malnutrition in children with CLD.
American Psychological Association (APA)
Elkabbany, Z. A.& Hamza, Rasha T.& Mahmoud, N. H.. 2014. Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050097
Modern Language Association (MLA)
Elkabbany, Z. A.…[et al.]. Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1050097
American Medical Association (AMA)
Elkabbany, Z. A.& Hamza, Rasha T.& Mahmoud, N. H.. Assessment of Serum Acylated Ghrelin in Children and Adolescents with Chronic Liver Diseases: Relation to Nutritional Status. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050097