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Significance of Algal Polymer in Designing Amphotericin B Nanoparticles
Joint Authors
Bhatia, Saurabh
Kumar, Vikash
Sharma, Kiran
Nagpal, Kalpana
Bera, Tanmoy
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-12
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Development of oral amphotericin B (AmB) loaded nanoparticles (NPs) demands a novel technique which reduces its toxicity and other associated problems.
Packing of AmB in between two oppositely charged ions by polyelectrolyte complexation technique proved to be a successful strategy.
We have developed a novel carrier system in form of polyelectrolyte complex of AmB by using chitosan (CS) and porphyran (POR) as two oppositely charged polymers with TPP as a crosslinking agent.
Initially POR was isolated from Porphyra vietnamensis followed by the fact that its alkali induced safe reduction in molecular weight was achieved.
Formulation was optimized using three-factor three-level (33) central composite design.
High concentration of POR in NPs was confirmed by sulfated polysaccharide (SP) assay.
Degradation and dissolution studies suggested the stability of NPs over wide pH range.
Hemolytic toxicity data suggested the safety of prepared formulation.
In vivo and in vitro antifungal activity demonstrated the high antifungal potential of optimized formulation when compared with standard drug and marketed formulations.
Throughout the study TPP addition did not cause any significant changes.
Therefore, these experimental oral NPs may represent an interesting carrier system for the delivery of AmB.
American Psychological Association (APA)
Bhatia, Saurabh& Kumar, Vikash& Sharma, Kiran& Nagpal, Kalpana& Bera, Tanmoy. 2014. Significance of Algal Polymer in Designing Amphotericin B Nanoparticles. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1050119
Modern Language Association (MLA)
Bhatia, Saurabh…[et al.]. Significance of Algal Polymer in Designing Amphotericin B Nanoparticles. The Scientific World Journal No. 2014 (2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1050119
American Medical Association (AMA)
Bhatia, Saurabh& Kumar, Vikash& Sharma, Kiran& Nagpal, Kalpana& Bera, Tanmoy. Significance of Algal Polymer in Designing Amphotericin B Nanoparticles. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1050119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050119