Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT
Joint Authors
Ponnan, Prija
Kumar, Ajit
Singh, Prabhjot
Gupta, Prachi
Joshi, Rini
Gaspari, Marco
Prasad, Ashok K.
Rastogi, Ramesh C.
Parmar, Virinder S.
Raj, Hanumantharao G.
Saso, Luciano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates to receptor proteins (RP).
Later, TAase was identified as calreticulin (CR), an endoplasmic reticulum luminal protein.
CR was termed calreticulin transacetylase (CRTAase).
Our persistent study revealed that CR like other families of histone acetyltransferases (HATs) such as p300, Rtt109, PCAF, and ESA1, undergoes autoacetylation.
The autoacetylated CR was characterized as a stable intermediate in CRTAase catalyzed protein acetylation, and similar was the case with ESA1.
The autoacetylation of CR like that of HATs was found to enhance protein-protein interaction.
CR like HAT-1, CBP, and p300 mediated the acylation of RP utilizing acetyl CoA and propionyl CoA as the substrates.
The similarities between CRTAase and HATs in mediating protein acylation are highlighted in this review.
American Psychological Association (APA)
Ponnan, Prija& Kumar, Ajit& Singh, Prabhjot& Gupta, Prachi& Joshi, Rini& Gaspari, Marco…[et al.]. 2014. Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050171
Modern Language Association (MLA)
Ponnan, Prija…[et al.]. Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050171
American Medical Association (AMA)
Ponnan, Prija& Kumar, Ajit& Singh, Prabhjot& Gupta, Prachi& Joshi, Rini& Gaspari, Marco…[et al.]. Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050171