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A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations
Joint Authors
Biradar, Jaiprakash S.
Rajesab, Parveen
Biradar, Naveen Jaiprakash
Somappa, Sasidhar Balappa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities.
The titled compounds (3a–z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a–c with 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl)prop-2-en-1-ones 2a–i.
All the newly synthesized compounds were characterized by IR, 1H NMR, mass spectroscopic and analytical data.
The synthesized analogues were tested for antioxidant and antimicrobial potency.
Among the tested compounds 3a–c and 3j–l have shown very promising free radical scavenging activity and total antioxidant capacity.
Compounds 3d–f, 3m–o, and 3s–z have shown excellent ferric reducing antioxidant activity.
An outstanding antimicrobial activity is observed with compounds 3a–c and 3j–l.
American Psychological Association (APA)
Biradar, Jaiprakash S.& Rajesab, Parveen& Biradar, Naveen Jaiprakash& Somappa, Sasidhar Balappa. 2014. A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050189
Modern Language Association (MLA)
Biradar, Jaiprakash S.…[et al.]. A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1050189
American Medical Association (AMA)
Biradar, Jaiprakash S.& Rajesab, Parveen& Biradar, Naveen Jaiprakash& Somappa, Sasidhar Balappa. A Mini Library of Novel Triazolothiadiazepinylindole Analogues: Synthesis, Antioxidant and Antimicrobial Evaluations. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050189