Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
Joint Authors
Iaccarino, G.
Sorriento, Daniela
Pascale, Antonietta Valeria
Finelli, Rosa
Carillo, Anna Lisa
Annunziata, Roberto
Trimarco, Bruno
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders.
Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer.
Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario.
Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer.
Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
American Psychological Association (APA)
Sorriento, Daniela& Pascale, Antonietta Valeria& Finelli, Rosa& Carillo, Anna Lisa& Annunziata, Roberto& Trimarco, Bruno…[et al.]. 2014. Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050301
Modern Language Association (MLA)
Sorriento, Daniela…[et al.]. Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050301
American Medical Association (AMA)
Sorriento, Daniela& Pascale, Antonietta Valeria& Finelli, Rosa& Carillo, Anna Lisa& Annunziata, Roberto& Trimarco, Bruno…[et al.]. Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050301