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Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma
Joint Authors
Chen, Long-Hua
Huang, Suning
Dang, Yiwu
Chen, Gang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Overexpression of decoy receptor 3 (DcR3) have been reported in various classes of malignancies.
However, its expression and clinicopathological contribution in gliomas has not been fully elucidated.
Objective.
To explore the expression and clinical significance of DcR3 protein in relation to tumor cell differentiation and proliferation in glioma cell lines and tissues.
Methods.
One hundred and twenty-five samples of glioma patients and 18 cases of normal brain tissues were recruited.
The expression of DcR3 protein was detected using immunohistochemistry.
Tumor differentiation was assessed by histologic characters and the status of glial fibrillary acidic protein (GFAP).
Tumor cell labeling indexes (LIs) of Ki-67 and PCNA were also obtained.
The relationship between the DcR3 level and clinicopathological features was investigated, including tumor differentiation, LIs, and survival.
Meanwhile, the expression of DcR3 protein was also measured in the supernatants of 8 glioma cell lines and glioma cells freshly prepared from 8 human glioblastoma specimens by using western blot.
Results.
The level of DcR3 protein in gliomas was significantly higher than that in normal brain tissues ( P < 0.01 ).
DcR3 expression showed positive correlations with tumor pathological grade ( r = 0.621 , P < 0.01 ) and negative with GFAP expression ( r = - 0.489 , P < 0.01 ).
Furthermore, there were positive correlations between DcR3 expression and Ki-67, PCNA LIs ( r = 0.529 , P < 0.01 ; r = 0.556 , P < 0.01 ).
The survival in the DcR3 negative group was 50 ± 1.79 months, longer than that of the DcR3 positive group (48.36 ± 2.90), however, without significance ( P = 0.149 ) .
Different levels of DcR3 could also be detected in the culturing supernatants of all the 8 glioma cell lines and glioma cells freshly obtained from 8 human glioblastoma specimens.
Conclusions.
The overexpression of DcR3 might play a crucial role in the tumorigenesis, differentiation, and proliferation of glioma.
American Psychological Association (APA)
Huang, Suning& Chen, Gang& Dang, Yiwu& Chen, Long-Hua. 2014. Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1050306
Modern Language Association (MLA)
Huang, Suning…[et al.]. Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1050306
American Medical Association (AMA)
Huang, Suning& Chen, Gang& Dang, Yiwu& Chen, Long-Hua. Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1050306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050306