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In Silico Approach towards Designing Virtual Oligopeptides for HRSV
Joint Authors
Piramanayagam, Shanmughavel
Jain, Ruchi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
HRSV (human respiratory syncytial virus) is a serious cause of lower respiratory tract illness in infants and young children.
Designing inhibitors from the proteins involved in virus replication and infection process provides target for new therapeutic treatments.
In the present study, in silico docking was performed using motavizumab as a template to design motavizumab derived oligopeptides for developing novel anti-HRSV agents.
Additional simulations were conducted to study the conformational propensities of the oligopeptides and confirmed the hypothesis that the designed oligopeptide is highly flexible and capable of assuming stable confirmation.
Our study demonstrated the best specific interaction of GEKKLVEAPKS oligopeptide for glycoprotein strain A among various screened oligopeptides.
Encouraged by the results, we expect that the proposed scheme will provide rational choices for antibody reengineering which is useful for systematically identifying the possible ways to improve efficacy of existing antibody drugs.
American Psychological Association (APA)
Jain, Ruchi& Piramanayagam, Shanmughavel. 2014. In Silico Approach towards Designing Virtual Oligopeptides for HRSV. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1050330
Modern Language Association (MLA)
Jain, Ruchi& Piramanayagam, Shanmughavel. In Silico Approach towards Designing Virtual Oligopeptides for HRSV. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1050330
American Medical Association (AMA)
Jain, Ruchi& Piramanayagam, Shanmughavel. In Silico Approach towards Designing Virtual Oligopeptides for HRSV. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1050330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050330