![](/images/graphics-bg.png)
Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats
Joint Authors
Zhang, Zhiguo
Li, Yan
Pan, Jinghua
Liu, Hong
Wang, Wenlai
Bai, Dong
Xiang, Lihua
Xiao, Gary G.
Ju, Dahong
Fu, Xiaowei
Li, Ya’nan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia.
Our results show that RDE could inhibit bone loss of OVX rats after a 12-week treatment.
The microarray analysis showed that 68 genes were upregulated and that 100 genes were downregulated in femurs of the RDE group rats compared to those in the OVX group.
The Ingenuity Pathway Analysis (IPA) showed that several downregulated genes had the potential to code for proteins that were involved in the Wnt/β-catenin signaling pathway (Sost, Lrp6, Tcf7l2, and Alpl) and the RANKL/RANK signaling pathway (Map2k6 and Nfatc4).
These results revealed that the mechanism for an antiosteopenic effect of RDE might lie in the synchronous inhibitory effects on both the bone formation and the bone resorption, which is associated with modulating the Wnt/β-catenin signaling and the RANKL/RANK signaling.
American Psychological Association (APA)
Zhang, Zhiguo& Xiang, Lihua& Bai, Dong& Fu, Xiaowei& Wang, Wenlai& Li, Yan…[et al.]. 2014. Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1050480
Modern Language Association (MLA)
Zhang, Zhiguo…[et al.]. Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1050480
American Medical Association (AMA)
Zhang, Zhiguo& Xiang, Lihua& Bai, Dong& Fu, Xiaowei& Wang, Wenlai& Li, Yan…[et al.]. Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1050480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050480