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Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits
Joint Authors
Tatli, Ufuk
Üstün, Yakup
Kürkçü, Mehmet
Benlidayı, Mehmet Emre
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model.
Study Design.
Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups.
The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump.
The control group was administered only saline infusion for 15 minutes.
All rabbits were sacrificed on the 21st postoperative day.
Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles.
The data were analyzed statistically.
Results.
Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle.
This result was supported by the histomorphometric findings.
Conclusion.
The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact.
These effects may be regarded as base data and considered in numerous clinical situations including TMJ.
American Psychological Association (APA)
Tatli, Ufuk& Üstün, Yakup& Kürkçü, Mehmet& Benlidayı, Mehmet Emre. 2014. Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050497
Modern Language Association (MLA)
Tatli, Ufuk…[et al.]. Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1050497
American Medical Association (AMA)
Tatli, Ufuk& Üstün, Yakup& Kürkçü, Mehmet& Benlidayı, Mehmet Emre. Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050497