Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of Acinetobacter baumannii Susceptible to Musca domestica cecropin
Joint Authors
Gui, Shuiqing
Li, Rongjiang
Feng, Yongwen
Wang, Sanming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Multidrug-resistant (MDR) Acinetobacter baumannii infections are difficult to treat owing to the extremely limited armamentarium.
Expectations about antimicrobial peptides' use as new powerful antibacterial agents have been raised on the basis of their unique mechanism of action.
Musca domestica cecropin (Mdc), a novel antimicrobial peptide from the larvae of Housefly (Musca domestica), has potently active against Gram-positive and Gram-negative bacteria standard strain.
Here we evaluated the antibacterial activity of Mdc against clinical isolates of MDR-A.
baumannii and elucidate the related antibacterial mechanisms.
The minimal inhibitory concentration (MIC) of Mdc was 4 μg/mL.
Bactericidal kinetics of Mdc revealed rapid killing of A.
baumannii (30 min).
Flow cytometry using viability stain demonstrated that Mdc causes A.
baumannii membrane permeabilization in a concentration- and time-dependent process, which correlates with the bactericidal action.
Moreover, transmission electron microscopic (TEM) examination showed that Mdc is capable of disrupting the membrane of bacterial cells, resulting in efflux of essential cytoplasmic components.
Overall, Mdc could be a promising antibacterial agent for MDR-A.
baumannii infections.
American Psychological Association (APA)
Gui, Shuiqing& Li, Rongjiang& Feng, Yongwen& Wang, Sanming. 2014. Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of Acinetobacter baumannii Susceptible to Musca domestica cecropin. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050534
Modern Language Association (MLA)
Gui, Shuiqing…[et al.]. Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of Acinetobacter baumannii Susceptible to Musca domestica cecropin. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1050534
American Medical Association (AMA)
Gui, Shuiqing& Li, Rongjiang& Feng, Yongwen& Wang, Sanming. Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of Acinetobacter baumannii Susceptible to Musca domestica cecropin. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050534