Evaluation of single versus double intrauterine insemination (IUI)‎ on pregnancy rate

Abstract EN

Objective : To evaluate the impact of double intrauterine insemination on pregnancy rate.

Design: A prospective randomized controlled study.

Setting: Al Azhar University ART unit.

Subject and Method: One hundred twenty three infertile couples planned to be treated using artificial insemination of husband's semen (AIH) due to male subfertility or unexplained infertility were recruited in this study during the period August 2004 to November 2005.

Controlled Ovarian Hyperstimulation (COH) has been done using clomiphene citrate 100 mg tablet/day and hMG 75 IU ampoule / day.

Transvaginal folliculometrey has been used to assess follicular growth.

When one or more follicle(s) reached the diameter of 18 mm, hCG (10, 000 IU) IM injection was given, 30-34 hours later, single IUI performed for all patients (n = 123) in their first trial.

Couples whom did not achieve pregnancy in the first trial were subjected to the double insemination (at 30-34 hours from hCG triggering dose as well as in 24 hours later ) in their next cycle (n = 95).

Results: Pregnancy rate per treatment cycle found higher and statistically significant in double IUI than in single (8.

4.

2 % and 6.

50 % respectively)