Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study
Joint Authors
D’Oliveira Albanus, Ricardo
Siqueira Dalmolin, Rodrigo Juliani
Rybarczyk-Filho, José Luiz
Alves Castro, Mauro Antônio
Fonseca Moreira, José Cláudio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Chemoreception is among the most important sensory modalities in animals.
Organisms use the ability to perceive chemical compounds in all major ecological activities.
Recent studies have allowed the characterization of chemoreceptor gene families.
These genes present strikingly high variability in copy numbers and pseudogenization degrees among different species, but the mechanisms underlying their evolution are not fully understood.
We have analyzed the functional networks of these genes, their orthologs distribution, and performed phylogenetic analyses in order to investigate their evolutionary dynamics.
We have modeled the chemosensory networks and compared the evolutionary constraints of their genes in Mus musculus, Homo sapiens, and Rattus norvegicus.
We have observed significant differences regarding the constraints on the orthologous groups and network topologies of chemoreceptors and signal transduction machinery.
Our findings suggest that chemosensory receptor genes are less constrained than their signal transducing machinery, resulting in greater receptor diversity and conservation of information processing pathways.
More importantly, we have observed significant differences among the receptors themselves, suggesting that olfactory and bitter taste receptors are more conserved than vomeronasal receptors.
American Psychological Association (APA)
D’Oliveira Albanus, Ricardo& Siqueira Dalmolin, Rodrigo Juliani& Rybarczyk-Filho, José Luiz& Alves Castro, Mauro Antônio& Fonseca Moreira, José Cláudio. 2014. Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050659
Modern Language Association (MLA)
D’Oliveira Albanus, Ricardo…[et al.]. Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050659
American Medical Association (AMA)
D’Oliveira Albanus, Ricardo& Siqueira Dalmolin, Rodrigo Juliani& Rybarczyk-Filho, José Luiz& Alves Castro, Mauro Antônio& Fonseca Moreira, José Cláudio. Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050659