The Effect of Sufentanil Administration on Remifentanil-Based Anaesthesia during Laparoscopic Gynaecological Surgery: A Double-Blind Randomized Controlled Trial

Abstract EN

This study assessed the effect of sufentanil administered before conclusion of remifentanil-based anaesthesia on postoperative hyperalgesia and haemodynamic stability in patients undergoing laparoscopic gynaecological surgery.

The patients were randomly allocated to a sufentanil administration group (S group) or a normal saline administration group (C group).

Anaesthesia was induced and maintained with controlled administration of remifentanil at 10 ng·mL−1 and propofol under bispectral index guidance.

Once the surgical specimen was procured, sufentanil or normal saline was administered at 0.15 ng·mL−1 and maintained until extubation.

The haemodynamic status during anaesthetic emergence was evaluated.

The pain and postoperative nausea and vomiting (PONV) were assessed for 72 h following postanaesthetic care unit (PACU) discharge.

The S group had significantly lower mean systemic arterial blood pressure and heart rate changes between the start of drug administration and extubation.

Postoperative pain was significantly lower in the S group until 24 h following PACU discharge.

There were no significant differences in PONV incidence and severity 72 h after PACU discharge between the two groups.

Sufentanil administration before concluding remifentanil-based anaesthesia improved postoperative hyperalgesia and achieved haemodynamic stability at extubation without delaying recovery or increasing PONV during laparoscopic gynaecological surgery.

Clinical trial registration is found at KCT0000785.