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Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
Joint Authors
Novotná, Eva
Saxena, Shalini
Yogeeswari, Perumal
Sriram, Dharmarajan
Švarcová, Markéta
Krátký, Martin
Vinšová, Jarmila
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase.
The enzymes are related to the nongrowing state of Mycobacterium tuberculosis.
Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase.
The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 µM and the best docking results.
Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates.
American Psychological Association (APA)
Krátký, Martin& Saxena, Shalini& Yogeeswari, Perumal& Sriram, Dharmarajan& Švarcová, Markéta& Vinšová, Jarmila…[et al.]. 2014. Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050681
Modern Language Association (MLA)
Saxena, Shalini…[et al.]. Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1050681
American Medical Association (AMA)
Krátký, Martin& Saxena, Shalini& Yogeeswari, Perumal& Sriram, Dharmarajan& Švarcová, Markéta& Vinšová, Jarmila…[et al.]. Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1050681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050681