Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting
Joint Authors
Bhardwaj, Peeyush
Chaurasia, Deepti
Singh, Ranjit
Swarup, Anoop
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability.
The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM).
The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF) at pH 1.2.
The yield of microspheres was obtained up to 84.46 ± 6.47 %.
Microspheres showed passable flow properties.
Based on optical microscopy, particle size was found to be ranging from 158.65 ± 12.02 to 198.67 ± 17.45 μ m.
SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres.
Different kinetic models for drug release were also applied on selected batches.
American Psychological Association (APA)
Bhardwaj, Peeyush& Chaurasia, Deepti& Singh, Ranjit& Swarup, Anoop. 2014. Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1050690
Modern Language Association (MLA)
Bhardwaj, Peeyush…[et al.]. Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1050690
American Medical Association (AMA)
Bhardwaj, Peeyush& Chaurasia, Deepti& Singh, Ranjit& Swarup, Anoop. Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1050690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050690