Molecular Alterations of PI3KAktmTOR Pathway: A Therapeutic Target in Endometrial Cancer
Joint Authors
Pavlidou, Athanasia
Vlahos, Nikos F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation.
It has also been suggested that its deregulation is associated with cancer.
Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers.
Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer.
This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer.
In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented.
American Psychological Association (APA)
Pavlidou, Athanasia& Vlahos, Nikos F.. 2014. Molecular Alterations of PI3KAktmTOR Pathway: A Therapeutic Target in Endometrial Cancer. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050713
Modern Language Association (MLA)
Pavlidou, Athanasia& Vlahos, Nikos F.. Molecular Alterations of PI3KAktmTOR Pathway: A Therapeutic Target in Endometrial Cancer. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050713
American Medical Association (AMA)
Pavlidou, Athanasia& Vlahos, Nikos F.. Molecular Alterations of PI3KAktmTOR Pathway: A Therapeutic Target in Endometrial Cancer. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050713
