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The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices
Joint Authors
Zangiabadi, Nasser
Asadi, Ali Reza
Jafari, Mandana
Mohtashami, Hossein
Hojatipour, Mahboobeh
Shabani, Mohammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients.
In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated.
Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ).
Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups.
The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks.
Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group.
Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats.
Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats.
American Psychological Association (APA)
Zangiabadi, Nasser& Mohtashami, Hossein& Hojatipour, Mahboobeh& Jafari, Mandana& Asadi, Ali Reza& Shabani, Mohammad. 2014. The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050765
Modern Language Association (MLA)
Zangiabadi, Nasser…[et al.]. The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050765
American Medical Association (AMA)
Zangiabadi, Nasser& Mohtashami, Hossein& Hojatipour, Mahboobeh& Jafari, Mandana& Asadi, Ali Reza& Shabani, Mohammad. The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050765