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Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats
Joint Authors
Schaalan, Mona F.
Abbas, Samah S.
Bahgat, Ashraf K.
El-Denshary, Ezzeddin S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In the present study, we investigated the potential beneficial impact of the addition of antioxidant supplements to diclofenac regimen in a model of carrageenan-induced paw.
Rats were treated daily with antioxidants, that is, a-lipoic acid (50 mg/kg), selenium (2.5 mg/kg), vitamin C (1 g/kg), vitamin E (300 mg/kg), or zinc (25 mg/kg) on seven successive days and then received a single treatment with diclofenac or saline before carrageenan was injected to induce paw inflammation.
The results indicated that these combinations did not significantly affect the percentage inhibition of paw edema caused by diclofenac alone; however, some combination treatments ameliorated signs of concomitant oxidative stress (such as alterations in plasma malondialdehyde (MDA) levels, hemolysate reduced glutathione levels, and erythrocytic superoxide dismutase enzyme activities) imparted by diclofenac alone.
In some cases, few tested antioxidants in combination with diclofenac resulted in increased plasma levels of interleukin- (IL-) 6 and C-reactive protein (CRP).
In conclusion, the results of these studies suggested to us that the added presence of natural antioxidants could be beneficial as standard anti-inflammatory therapeutics for a patient under diclofenac treatment, albeit that these effects do not appear to significantly build upon those that could be obtained from this common anti-inflammatory agent per se.
American Psychological Association (APA)
Abbas, Samah S.& Schaalan, Mona F.& Bahgat, Ashraf K.& El-Denshary, Ezzeddin S.. 2014. Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050816
Modern Language Association (MLA)
Abbas, Samah S.…[et al.]. Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050816
American Medical Association (AMA)
Abbas, Samah S.& Schaalan, Mona F.& Bahgat, Ashraf K.& El-Denshary, Ezzeddin S.. Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050816