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Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents
Joint Authors
Sharma, Neha
Kajal, Anu
Bala, Suman
Kamboj, Sunil
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A series of benzamide substituted Mannich bases (1–7) were synthesized.
The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs.
The compounds 5, 6, and 7 were found to be the most active antibacterial agents among all the synthesized compounds.
The physicochemical similarity of the compounds with standard drugs was assessed by calculating various physicochemical properties using software programs.
The percent similarity of synthesized compounds was found to be good and compound 1 was found to have higher percentage of similarity.
The compounds were subjected to QSAR by multilinear regression using Analyze it version 3.0 software, and four statistically sound models were developed with R 2 (0.963–0.997), R a d j 2 (0.529–0.982), and Q 2 (0.998–0.999) with good F (2.35–65.56) values.
American Psychological Association (APA)
Bala, Suman& Sharma, Neha& Kajal, Anu& Kamboj, Sunil. 2014. Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050820
Modern Language Association (MLA)
Bala, Suman…[et al.]. Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050820
American Medical Association (AMA)
Bala, Suman& Sharma, Neha& Kajal, Anu& Kamboj, Sunil. Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050820