Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Since apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology.
Radiolabeled annexin V compounds are the hallmark in apoptosis imaging in vivo.
These compounds are reviewed from the genesis of apoptosis (cell death) imaging agents up to recent years.
They have some disadvantages, including slow clearance and immunogenicity, because they are protein-based imaging agents.
For this reason, several studies have been conducted in recent years to develop low molecule apoptosis imaging agents.
In this review, radiolabeled phosphatidylserine targeted peptides, radiolabeled bis(zinc(II)-dipicolylamine) complex, radiolabeled 5-fluoropentyl-2-methyl-malonic acid (ML-10), caspase-3 activity imaging agents, radiolabeled duramycin, and radiolabeled phosphonium cation are reviewed as promising low-molecular-weight apoptosis imaging agents.
American Psychological Association (APA)
Ogawa, Kazuma& Aoki, Miho. 2014. Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1050821
Modern Language Association (MLA)
Ogawa, Kazuma& Aoki, Miho. Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1050821
American Medical Association (AMA)
Ogawa, Kazuma& Aoki, Miho. Radiolabeled Apoptosis Imaging Agents for Early Detection of Response to Therapy. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1050821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050821