In Vivo Healing Potential of Aegle marmelos in Excision, Incision, and Dead Space Wound Models
Joint Authors
Gautam, M. K.
Purohit, V.
Agarwal, M.
Singh, A.
Goel, R. K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The study incorporates the wound healing potential of Aegle marmelos fruit pulp extract (AME) on excision, incision, and dead space wound models in rats.
AME (200 mg/kg) was administered orally once daily for variable days depending on the type of wound ulcer study.
AME was studied for its wound breaking strength (incision wound), rate of contraction, period of epithelization and histology of skin (excision model), and granulation tissue free radicals, antioxidants, acute inflammatory marker, and connective tissue markers and deep connective tissue histology (dead space wound).
Complete wound contraction and epithelization were observed at the 20th day after treatment with AME as compared to the 24th day in control rats.
Mean epithelization period and scar area were decreased while wound breaking strength was increased with AME compared with control.
Granulation tissue showed increased levels of collagen determinants (33.7 to 64.4%, P < 0.001 ) and antioxidants (13.0 to 38.8%, P < 0.05 to P < 0.001 ), whereas markers of oxidative stress (55.0 to 55.6%, P < 0.001 ) and myeloperoxidase (21.3%, P < 0.001 ) were decreased in AME treated group.
A.
marmelos seems to promote wound healing by enhancing connective tissue formation and antioxidants status with decrease in free radicals and myeloperoxidase having tissue damaging effects.
American Psychological Association (APA)
Gautam, M. K.& Purohit, V.& Agarwal, M.& Singh, A.& Goel, R. K.. 2014. In Vivo Healing Potential of Aegle marmelos in Excision, Incision, and Dead Space Wound Models. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050847
Modern Language Association (MLA)
Gautam, M. K.…[et al.]. In Vivo Healing Potential of Aegle marmelos in Excision, Incision, and Dead Space Wound Models. The Scientific World Journal No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1050847
American Medical Association (AMA)
Gautam, M. K.& Purohit, V.& Agarwal, M.& Singh, A.& Goel, R. K.. In Vivo Healing Potential of Aegle marmelos in Excision, Incision, and Dead Space Wound Models. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1050847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050847