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Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C
Joint Authors
Lu, Wan-Jung
Huang, Yung-Kai
Lan, Chang-Chou
Hsia, Chih-Hsuan
Lee, Hsiu-Chuan
Lee, Tzu-Yin
Lin, Shih-Chang
Sheu, Joen-Rong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Antrodia camphorata is a rare Taiwanese medicinal mushroom.
Antrodia camphorata extract has been reported to exhibit antioxidant, anti-inflammation, antimetastasis, and anticancer activities and plays a role in liver fibrosis, vasorelaxation, and immunomodulation.
Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis.
Platelet activation plays a crucial role in intravascular thrombosis, which is involved in a wide variety of cardiovascular diseases.
However, the effect of Antrodia camphorata on platelet activation remains unclear.
We examined the effects of Antrodia camphorata on platelet activation.
In the present study, Antrodia camphorata treatment (56–224 μg/mL) inhibited platelet aggregation induced by collagen, but not U46619, an analogue of thromboxane A2, thrombin, and arachidonic acid.
Antrodia camphorata inhibited collagen-induced calcium ( Ca 2 + ) mobilization and phosphorylation of protein kinase C (PKC) and Akt.
In addition, Antrodia camphorata significantly reduced the aggregation and phosphorylation of PKC in phorbol-12, 13-dibutyrate (PDBu) activated platelets.
In conclusion, Antrodia camphorata may inhibit platelet activation by inhibiting of Ca 2 + and PKC cascade and the Akt pathway.
Our study suggests that Antrodia camphorata may be a potential therapeutic agent for preventing or treating thromboembolic disorders.
American Psychological Association (APA)
Lu, Wan-Jung& Lin, Shih-Chang& Lan, Chang-Chou& Lee, Tzu-Yin& Hsia, Chih-Hsuan& Huang, Yung-Kai…[et al.]. 2014. Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050875
Modern Language Association (MLA)
Lu, Wan-Jung…[et al.]. Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050875
American Medical Association (AMA)
Lu, Wan-Jung& Lin, Shih-Chang& Lan, Chang-Chou& Lee, Tzu-Yin& Hsia, Chih-Hsuan& Huang, Yung-Kai…[et al.]. Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050875