Validity of Cardiovascular Risk Prediction Models in Kidney Transplant Recipients
Joint Authors
Shoker, Ahmed
Mansell, Holly
Stewart, Samuel Alan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Predicting cardiovascular risk is of great interest in renal transplant recipients since cardiovascular disease is the leading cause of mortality.
Objective.
To conduct a systematic review to assess the validity of cardiovascular risk prediction models in this population.
Methods.
Five databases were searched (MEDLINE, EMBASE, SCOPUS, CINAHL, and Web of Science) and cohort studies with at least one year of follow-up were included.
Variables that described population characteristics, study design, and prognostic performance were extracted.
The Quality in Prognostic Studies (QUIPS) tool was used to evaluate bias.
Results.
Seven studies met the criteria for inclusion, of which, five investigated the Framingham risk score and three used a transplant-specific model.
Sample sizes ranged from 344 to 23,575, and three studies lacked sufficient event rates to confidently reach conclusion.
Four studies reported discrimination (as measured by c-statistic), which ranged from 0.701 to 0.75, while only one risk model was both internally and externally validated.
Conclusion.
The Framingham has underestimated cardiovascular events in renal transplant recipients, but these studies have not been robust.
A risk prediction model has been externally validated at least on one occasion, but comprehensive validation in multiple cohorts and impact analysis are recommended before widespread clinical application is advocated.
American Psychological Association (APA)
Mansell, Holly& Stewart, Samuel Alan& Shoker, Ahmed. 2014. Validity of Cardiovascular Risk Prediction Models in Kidney Transplant Recipients. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1050899
Modern Language Association (MLA)
Mansell, Holly…[et al.]. Validity of Cardiovascular Risk Prediction Models in Kidney Transplant Recipients. The Scientific World Journal No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1050899
American Medical Association (AMA)
Mansell, Holly& Stewart, Samuel Alan& Shoker, Ahmed. Validity of Cardiovascular Risk Prediction Models in Kidney Transplant Recipients. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1050899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050899