Potent Antioxidative and UVB Protective Effect of Water Extract of Eclipta prostrata L.
Joint Authors
Chan, Chin-Feng
Huang, Wen-Ying
Guo, Hong-Yi
Wang, Bo Rong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Oxidative stress, including Ultraviolet (UV) irradiation-induced skin damage, is involved in numerous diseases.
This study demonstrates that water extract of Eclipta prostrata L.
(WEP) has a potent effect in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radicals, and chelating ferrous ion, exhibiting IC50 values of 0.23 mg/mL, 0.48 mg/mL, and 1.25 mg/mL, respectively.
The WEP total phenol content was 176.45 mg gallic acid equivalents (GAE)/g sample.
Chlorogenic acid, a component of the plant's active ingredients, was determined by HPLC and antioxidative assay.
However, no caffeic acid, stigmasterol, or wedelolactone was present in WEP.
WEP absorbs both UVA and UVB irradiation, and furthermore, the extract shows a dose-dependent response in the protection of HaCaT human keratinocytes and mouse fibroblasts 3T3 cells against UVB-induced cytotoxicity, which may result from a synergistic effect between chlorogenic acid and other active components present in WEP.
American Psychological Association (APA)
Chan, Chin-Feng& Huang, Wen-Ying& Guo, Hong-Yi& Wang, Bo Rong. 2014. Potent Antioxidative and UVB Protective Effect of Water Extract of Eclipta prostrata L.. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050942
Modern Language Association (MLA)
Chan, Chin-Feng…[et al.]. Potent Antioxidative and UVB Protective Effect of Water Extract of Eclipta prostrata L.. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050942
American Medical Association (AMA)
Chan, Chin-Feng& Huang, Wen-Ying& Guo, Hong-Yi& Wang, Bo Rong. Potent Antioxidative and UVB Protective Effect of Water Extract of Eclipta prostrata L.. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050942