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The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells
Joint Authors
Zhu, Jianhua
Yu, Rongmin
Wu, Yu
Hu, Xianjing
Song, Liyan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Inflammation is known to be closely associated with the development of cancer.
The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata.
The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-α in human cervical cancer HeLa cells.
For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells.
In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators.
All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy.
American Psychological Association (APA)
Wu, Yu& Hu, Xianjing& Song, Liyan& Zhu, Jianhua& Yu, Rongmin. 2014. The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050985
Modern Language Association (MLA)
Wu, Yu…[et al.]. The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050985
American Medical Association (AMA)
Wu, Yu& Hu, Xianjing& Song, Liyan& Zhu, Jianhua& Yu, Rongmin. The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050985