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A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health
Joint Authors
Tian, Rui
Hou, Gonglin
Li, Dan
Yuan, Ti-Fei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Sustained stress triggers series of changes in the brain and the body.
At the early stage of stress, the activated hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) axis can upregulate the levels of glucocorticoid (GCs) and catecholamines (CAs), respectively, and then they in turn inhibit the secretion of proinflammatory cytokines directly or indirectly while promoting the secretion of anti-inflammatory cytokines.
At the prolonged stage, the sustained activated HPA demonstrates cortisol-resistance.
At the same time, the inflammation related transcription pathway, such as nuclear-factor kappa-B (NF-κB) signaling, may be inhibited.
Additionally, the inflammatory cytokines mediate a negative feedback regulation on themselves.
Collectively, these regulations may increase the proinflammatory cytokines while decreasing the anti-inflammatory cytokines.
This may further activate NF-κB and increase the proinflammation cytokines, which in turn reduce the inflammatory responses, contributing to various diseases.
American Psychological Association (APA)
Tian, Rui& Hou, Gonglin& Li, Dan& Yuan, Ti-Fei. 2014. A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050997
Modern Language Association (MLA)
Tian, Rui…[et al.]. A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050997
American Medical Association (AMA)
Tian, Rui& Hou, Gonglin& Li, Dan& Yuan, Ti-Fei. A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050997