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Protective Effect of Hesperetin and Naringenin against Apoptosis in IschemiaReperfusion-Induced Retinal Injury in Rats
Joint Authors
Gencer, Baran
Ersan, Ismail
Karaca, Turan
Karaboga, Ihsan
Hanci, Volkan
Kara, Selcuk
Tufan, Hasan Ali
Arikan, Sedat
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
Hesperetin and naringenin are naturally common flavonoids reported to have antioxidative effects.
This study was performed to investigate whether either hesperetin or naringenin has a protective effect against apoptosis on retinal ischemia/reperfusion (I/R) injury.
Methods.
Retinal I/R was induced by increasing the intraocular pressure to 150 mmHg for 60 minutes.
Thirty-three male Wistar albino rats were randomised into 5 groups named control, I/R + sham, I/R + solvent (DMSO), I/R + hesperetin, and I/R + naringenin.
Animals were given either hesperetin, naringenin, or the solvent intraperitoneally immediately following reperfusion.
Thickness of retinal layers and retinal cell apoptosis were detected by histological analysis, tunel assay, and immunohistochemistry assay.
Results.
Hesperetin and naringenin attenuated the I/R-induced apoptosis of retinal cells in the inner and outer nuclear cells of the rat retina.
Retinal layer thickness of the naringenin treatment group was significantly thicker than that of the hesperetin, sham, and solvent groups ( P < 0.05 ).
Conclusions.
Hesperetin and naringenin can prevent harmful effects induced by I/R injury in the rat retina by inhibiting apoptosis of retinal cells, which suggests that those flavanones have a therapeutic potential for the protection of ocular ischemic diseases.
American Psychological Association (APA)
Kara, Selcuk& Gencer, Baran& Karaca, Turan& Tufan, Hasan Ali& Arikan, Sedat& Ersan, Ismail…[et al.]. 2014. Protective Effect of Hesperetin and Naringenin against Apoptosis in IschemiaReperfusion-Induced Retinal Injury in Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1051072
Modern Language Association (MLA)
Kara, Selcuk…[et al.]. Protective Effect of Hesperetin and Naringenin against Apoptosis in IschemiaReperfusion-Induced Retinal Injury in Rats. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1051072
American Medical Association (AMA)
Kara, Selcuk& Gencer, Baran& Karaca, Turan& Tufan, Hasan Ali& Arikan, Sedat& Ersan, Ismail…[et al.]. Protective Effect of Hesperetin and Naringenin against Apoptosis in IschemiaReperfusion-Induced Retinal Injury in Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1051072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051072