Lymphocyte Oxidative StressGenotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers
Joint Authors
Li, Yongfei
Xue, Xiao-Chang
Zheng, Aqun
Chen, Lan
Kong, Yu
Gao, Mei-li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We investigated oxidative stress/genotoxic effects levels, immunoglobulin levels, polycyclic aromatic hydrocarbons (PAHs) levels exposed in 126 coke oven workers and in 78 control subjects, and evaluated the association between oxidative stress/genotoxic effects levels and immunoglobulin levels.
Significant differences were observed in biomarkers, including 1-hydroxypyrene levels, employment time, percentages of alcohol drinkers, MDA, 8-OHdG levels, CTL levels and CTM, MN, CA frequency, and IgG, IgA levels between the control and exposed groups.
Slightly higher 1-OHP levels in smoking users were observed.
For the dose-response relationship of IgG, IgA, IgM, and IgE by 1-OHP, each one percentage increase in urinary 1-OHP generates a 0.109%, 0.472%, 0.051%, and 0.067% decrease in control group and generates a 0.312%, 0.538%, 0.062%, and 0.071% decrease in exposed group, respectively.
Except for age, alcohol and smoking status, IgM, and IgE, a significant correlation in urinary 1-OHP and other biomarkers in the total population was observed.
Additionally, a significant negative correlation in genotoxic/oxidative damage biomarkers of MDA, 8-OH-dG, CTL levels, and immunoglobins of IgG and IgA levels, especially in coke oven workers, was found.
These data suggest that oxidative stress/DNA damage induced by PAHs may play a role in toxic responses for PAHs in immunological functions.
American Psychological Association (APA)
Gao, Mei-li& Li, Yongfei& Zheng, Aqun& Xue, Xiao-Chang& Chen, Lan& Kong, Yu. 2014. Lymphocyte Oxidative StressGenotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051078
Modern Language Association (MLA)
Gao, Mei-li…[et al.]. Lymphocyte Oxidative StressGenotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1051078
American Medical Association (AMA)
Gao, Mei-li& Li, Yongfei& Zheng, Aqun& Xue, Xiao-Chang& Chen, Lan& Kong, Yu. Lymphocyte Oxidative StressGenotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1051078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051078