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Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
Joint Authors
Shenoy, Rekha R.
Kondamudi, Phani Krishna
Kovelamudi, Hemalatha
Mathew, Geetha
Rao, C. Mallikarjuna
Nayak, Pawan G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin.
In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats.
Methods.
The groups were divided into normal control, AA control, SES, and sulfasalazine (SS).
On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed.
Results.
The levels of MPO, TBARS, and tissue nitrite increased significantly (P<0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups.
Serum nitrite levels were found to be insignificant between the different groups.
Conclusions.
The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.
American Psychological Association (APA)
Kondamudi, Phani Krishna& Kovelamudi, Hemalatha& Mathew, Geetha& Nayak, Pawan G.& Rao, C. Mallikarjuna& Shenoy, Rekha R.. 2014. Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051091
Modern Language Association (MLA)
Kondamudi, Phani Krishna…[et al.]. Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051091
American Medical Association (AMA)
Kondamudi, Phani Krishna& Kovelamudi, Hemalatha& Mathew, Geetha& Nayak, Pawan G.& Rao, C. Mallikarjuna& Shenoy, Rekha R.. Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051091