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How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?
Joint Authors
Heer, M.
Baecker, Natalie
Wnendt, Stephan
Fischer, Annelie
Biolo, Gianni
Frings-Meuthen, Petra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Aim.
We hypothesized that 4 days of normal daily activity after 21 days of experimental bed rest (BR) will not reverse BR induced impaired glucose tolerance.
Design.
Glucose tolerance of seven male, healthy, untrained test subjects (age: 27.6 (3.3) years (mean (SD)); body mass: 78.6 (6.4) kg; height: 1.81 (0.04) m; VO2 max: 39.5 (5.4) ml/kg body mass/min) was studied.
They stayed twice in the metabolic ward (crossover design), 21 days in bed and 7 days before and after BR each.
Oral glucose tolerance tests were applied before, on day 21 of BR, and 5 and 14 days after BR.
Results.
On day 21 of BR, AUC120 min of glucose concentration was increased by 28.8 (5.2)% and AUC120 min of insulin by 35.9 (10.2)% (glucose: P < 0.001 ; insulin: P = 0.02 ).
Fourteen days after BR, AUC120 min of serum insulin concentrations returned to pre-bed-rest concentrations ( P = 0.352 ) and AUC120 min of glucose was still higher ( P = 0.038 ).
Insulin resistance did not change, but sensitivity index was reduced during BR ( P = 0.005 ).
Conclusion.
Four days of light physical workload does not compensate inactivity induced impaired glucose tolerance.
An individually tailored and intensified training regime is mandatory in patients being in bed rest to get back to normal glucose metabolism in a reasonable time frame.
American Psychological Association (APA)
Heer, M.& Baecker, Natalie& Wnendt, Stephan& Fischer, Annelie& Biolo, Gianni& Frings-Meuthen, Petra. 2014. How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051095
Modern Language Association (MLA)
Heer, M.…[et al.]. How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1051095
American Medical Association (AMA)
Heer, M.& Baecker, Natalie& Wnendt, Stephan& Fischer, Annelie& Biolo, Gianni& Frings-Meuthen, Petra. How Fast Is Recovery of Impaired Glucose Tolerance after 21-Day Bed Rest (NUC Study) in Healthy Adults?. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1051095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051095