Simulation of Contrast Agent Transport in Arteries with Multilayer Arterial Wall: Impact of Arterial Transmural Transport on the Bolus Delay and Dispersion
Joint Authors
Fan, Yubo
Li, De-Yu
Xu, Min
Liu, Xiao
Li, Ang
Sun, Anqiang
Deng, Xiaoyan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
One assumption of DSC-MRI is that the injected contrast agent is kept totally intravascular and the arterial wall is impermeable to contrast agent.
The assumption is unreal for such small contrast agent as Gd-DTPA can leak into the arterial wall.
To investigate whether the unreal assumption is valid for the estimation of the delay and dispersion of the contrast agent bolus, we simulated flow and Gd-DTPA transport in a model with multilayer arterial wall and analyzed the bolus delay and dispersion qualified by mean vascular transit time (MVTT) and the variance of the vascular transport function.
Factors that may affect Gd-DTPA transport hence the delay and dispersion were further investigated, such as integrity of endothelium and disturbed flow.
The results revealed that arterial transmural transport would slightly affect MVTT and moderately increase the variance.
In addition, although the integrity of endothelium can significantly affect the accumulation of contrast agent in the arterial wall, it had small effects on the bolus delay and dispersion.
However, the disturbed flow would significantly increase both MVTT and the variance.
In conclusion, arterial transmural transport may have a small effect on the bolus delay and dispersion when compared to the flow pattern in the artery.
American Psychological Association (APA)
Xu, Min& Liu, Xiao& Li, Ang& Fan, Yubo& Sun, Anqiang& Deng, Xiaoyan…[et al.]. 2014. Simulation of Contrast Agent Transport in Arteries with Multilayer Arterial Wall: Impact of Arterial Transmural Transport on the Bolus Delay and Dispersion. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1051096
Modern Language Association (MLA)
Xu, Min…[et al.]. Simulation of Contrast Agent Transport in Arteries with Multilayer Arterial Wall: Impact of Arterial Transmural Transport on the Bolus Delay and Dispersion. The Scientific World Journal No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1051096
American Medical Association (AMA)
Xu, Min& Liu, Xiao& Li, Ang& Fan, Yubo& Sun, Anqiang& Deng, Xiaoyan…[et al.]. Simulation of Contrast Agent Transport in Arteries with Multilayer Arterial Wall: Impact of Arterial Transmural Transport on the Bolus Delay and Dispersion. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1051096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051096