The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions
Joint Authors
Kaczmarek, A.
Cielecka-Piontek, J.
Zalewski, P.
Oszczapowicz, I.
Piekarski, Mikołaj
Firlej, Artur
Jelińska, Anna
Kycler, Witold
Dołhań, Agnieszka
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin hydrochloride (PPD) was investigated.
Degradation was studied using an HPLC method.
Specific acid-base catalysis of PPD involves hydrolysis of protonated molecules of PPD catalyzed by hydrogen ions and spontaneous hydrolysis under the influence of water zwitterions, unprotonated molecules, and monoanions of PPD.
The thermodynamic parameters of these reactions, energy, enthalpy, and entropy, were calculated.
Also, the stability of daunorubicin and its new amidine derivatives (piperidine, morpholine, pyrrolidine, and hexahydroazepin-1-yl) in aqueous solutions was compared and discussed.
American Psychological Association (APA)
Piekarski, Mikołaj& Dołhań, Agnieszka& Cielecka-Piontek, J.& Zalewski, P.& Kycler, Witold& Kaczmarek, A.…[et al.]. 2014. The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051098
Modern Language Association (MLA)
Piekarski, Mikołaj…[et al.]. The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions. The Scientific World Journal No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1051098
American Medical Association (AMA)
Piekarski, Mikołaj& Dołhań, Agnieszka& Cielecka-Piontek, J.& Zalewski, P.& Kycler, Witold& Kaczmarek, A.…[et al.]. The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1051098
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051098
