Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver
Joint Authors
Mohammadi, Mustafa
Ghaznavi, Rana
Keyhanmanesh, Rana
Sadeghipour, Hamid Reza
Naderi, Roya
Mohammadi, Hossein
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The aim of the present study is to investigate the effects of caloric restriction on liver of lead-administered rat.
Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access to normal rat chow) and caloric restriction group (CR, fed 65% of AL animals’ food intake).
After 6 weeks, half of the animals of each group were injected lead acetate and the other half were injected saline.
Liver tissue samples were collected at the end of the experiments.
Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the tissue extracts.
Histological studies were also performed.
Our results showed that lead administrations (not saline injections) reduced liver SOD and GPx and increased MDA and TNF-α in AL animals, but in the CR animals lead injections did not significantly change the measured parameters.
The histological studies supported the biochemical findings.
We concluded that 65% CR may prevent lead-induced oxidative stress and inflammation in rat liver.
American Psychological Association (APA)
Mohammadi, Mustafa& Ghaznavi, Rana& Keyhanmanesh, Rana& Sadeghipour, Hamid Reza& Naderi, Roya& Mohammadi, Hossein. 2014. Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051198
Modern Language Association (MLA)
Mohammadi, Mustafa…[et al.]. Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver. The Scientific World Journal No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1051198
American Medical Association (AMA)
Mohammadi, Mustafa& Ghaznavi, Rana& Keyhanmanesh, Rana& Sadeghipour, Hamid Reza& Naderi, Roya& Mohammadi, Hossein. Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051198